![]() The gene for the von Willebrand clotting factor (yellow) is expressed only in veins (V) in mouse brain (left), but is also expressed in capillaries (C) and arteries (A) in human brain (right). In particular, inflammatory signaling ramped up there in old mice. In the April 27 Cell, the researchers delineated a map of gene expression in this mouse choroid plexus, showing how profiles changed across ventricles and with age. CSF harbors key biomarkers of Alzheimer’s disease. This tissue lines ventricles and produces the cerebrospinal fluid that bathes the brain. Meanwhile, researchers led by Maria Lehtinen at Boston Children’s Hospital tackled another understudied brain tissue, the choroid plexus. “These results shed a different light on many AD-relevant genes,” Fiers noted. Mark Fiers at KU Leuven, Belgium, called it an important paper for the field. Louis wrote to Alzforum (full comment below). “This is an exciting story from Wyss-Coray’s lab, as now we finally have a beautiful atlas of endothelial and stromal cells from human brain and meninges,” Jonathan Kipnis at Washington University in St. “We need to explore the risk contribution of these different cell types to AD,” Wyss-Coray noted. ![]() Intriguingly, vascular cells expressed 30 of the top 45 AD risk genes, hinting that these understudied cells may play a larger role in pathogenesis than was previously thought. In AD brain samples, their analysis found numerous gene expression changes compared to healthy brain, and confirmed a massive loss of vascular cell types, particularly those responsible for maintaining the extracellular matrix.
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